HOFMANN DEGRADATION
AMIDES WITH NO SUBSTITUTIONON NITROGEN REACT WITH THE SOLUTION OF BROMINE OR CHLORINE IN NaOH OR KOH TOYIELD AMINES THROUGH A REACTION KNOWN AS THE HOFMANN DEGRADATION
R-C=O-NH2 + Br2 + 4NaOH ----------------> R-NH2 + 2NaBr + Na2CO3 + 2H2O
SCHIMDT REARRANGEMENT
THE REACTION OF CARBOXYLIC ACID WITH HYDRAZOIC ACID IN THE PRESENCE OF COCENTRATED SULPHURIC ACID TO GIVE ISOCYNATES IS KNOWN AS
SCIMDT REARRANGEMENT. IT OFFERS A CONVENIENT METHOD FOR THE CONVERSION OF ACIDS INTO p-AMINES AND HAS THE ADVANTAGE OVER HOFFMAN DUE TO BEING A ONE STEP REACTION.
C6H5COOH + N3H ---------------> C6H5-NH2
THE BECKMANN REARRANGEMENT
THE ACID CATALYSED CONVERSION OF CYTOXIMES TO n-SUBSTITUTED AMIDES IS CALLED THE BECKMANN REARRANGEMENT... ACID CATALYSED USED ARE PROTON ACIDS( H2SO4, HCl, ) AND LEWIS ACIDS ( PCl5 , RCOCl)
C6H5-C=(N-OH) ------------> CH3-COO-NH + C6H5
FURTHER ORGANIC TOPICS TO BE INCLUDED IN FURTHER POSTS..
AUTHOR:-
YASHVEER VAIS
FOR TOPICS FOR CLASS 12 , KINDLY VISIT:
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